Publications
2023
21) Interaction Metabolomics to Discover Synergists in Natural Product Mixtures
Warren S. Vidar, Tim U.H. Baumeister, Lindsay K. Caesar, Joshua J. Kellogg, Daniel A. Todd, Roger G. Linington, Olav M. Kvalheim, Nadja B. Cech
Journal of Natural Products
doi: 10.1012/acs.jnatprod.2c00518
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20) Correlative metabologenomics of 110 fungi reveals metabolite-gene cluster pairs
Lindsay K. Caesar, Fatma A. Butun, Matthew T. Robey, Navid J. Ayon, Raveena Gupta, David Dainko, Jin Woo Bok, Grant Nickles, Robert J. Stankey, Don Johnson, David Mead, Kristof B. Cank, Cody E. Earp, Huzefa A. Raja, Nicholas H. Oberlies, Nancy P. Keller, Neil L. Kelleher
Nature Chemical Biology
2022
19) Chalcones from Angelica keiskei (ashitaba) inhibit key Zika virus replication proteins
Melina Mottin, Lindsay K. Caesar, David Brodsky, Nathalya C.M.R. Mesquita, Ketllyn Zagatode, Oliveira Gabriela, Dias Nosked, Bruna K.P. Sousa, Paulo R.P.S. Ramosa, Hannah Jarmer, Bonnie Loh, Kimberley Zorn, Daniel Foil, Pedro M. Torres, Rafael V.C. Guido, Glaucius Oliva, Frank Scholle, Sean Ekins, Nadja B. Cech, Carolina H. Andrade, Scott M. Laster
Bioorganic Chemistry 120: 105649
2021
18) Metabolomics and Genomics in Natural Products Research: Complementary Tools for Targeting New Chemical Entities
Lindsay K. Caesar, Rana Montaser, Nancy P. Keller, Neil L. Kelleher
Natural Product Reports 38(11): 2041-2065
doi: 10.1039/d1np00036e
17) An Interpreted Atlas of Biosynthetic Gene Clusters from 1000 Fungal Genomes
Matthew T. Robey, Lindsay K. Caesar, Milton T. Drott, Nancy P. Keller, Neil L. Kelleher
PNAS 118(19): e2020230118
2020
​16) In the fungus where it happens: History and future propelling Aspergillus nidulans as the archetype of natural products research
Lindsay K. Caesar, Neil L. Kelleher, Nancy P. Keller
Fungal Genetics and Biology 144: 103477
doi: 10.1016/j.fgb.2020.103477
15) Heterologous expression of the unusual terreazepine biosynthetic gene cluster reveals a promising approach for identifying new chemical scaffolds
Lindsay K. Caesar, Matthew T. Robey, Michael Swyers, Md N. Islam, Rosa Y. Purav P. Vagadia, Gary Schiltz, Paul M. Thomas, Chengcang Wu, Neil L. Kelleher, Nancy P. Keller, Jin Woo Bok
mBio 11(4): e01691-20
14) Targeted and untargeted analysis of secondary metabolites to monitor growth and quorum sensing inhibition for methicillin-resistant Staphylococcus aureus (MRSA)
Derick D. Jones, Lindsay K. Caesar, Chantal V. Pelzer, William J. Crandall, Christian Jenul, Daniel A. Todd, Alexander R. Horswill, Nadja B. Cech
Journal of Microbiological Methods 176: 106000
doi: 10.1016/j.mimet.2020.106000
13) Chemical Evaluation of the Effects of Storage Conditions on the Botanical Goldenseal using Marker-based and Metabolomics Approaches
Manead Khin, Nadja B. Cech, Joshua J. Kellogg, Lindsay K. Caesar
Yale Journal of Biology and Medicine 93(2): 265-275
PMCID: PMC7309669
12) A novel biosynthetic pathway for linear peptide processing and export in Staphylococcus aureus
Katrin Schilcher, Lindsay K. Caesar, Nadja B. Cech, Alexander R. Horswill
mBio 11(2): e00112-20
2019
11) Simplify: A Mass Spectrometry Metabolomics Approach to Identify Additives and Synergists from Complex Mixtures
Lindsay K. Caesar, Sabina Nogo, Cassandra N. Naphen, Nadja B. Cech
Analytical Chemistry 91(17): 11297-11305
doi: 10.1021/acs.analchem.9b02377
10) Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2
Lindsay K. Caesar, Nadja B. Cech
Natural Product Reports 36: 869-888
doi: 10.1039/c9np00011a
9) Opportunities and Limitations for Untargeted Mass Spectrometry Metabolomics to Identify Biologically Active Constituents in Complex Natural Product Mixtures
Lindsay K. Caesar, Joshua J. Kellogg, Olav M. Kvalheim, Nadja B. Cech
Journal of Natural Products 82(3): 469-484
doi: 10.1021/acs.jnatprod.9b00176
8) Mapping the Fungal Battlefield: Using in situ Chemistry and Deletion Mutants to Monitor Interspecific Chemical Interactions Between Fungi
Sonja L. Knowles, Huzefa A. Raja, Allison J. Wright, Ann Marie L. Lee, Lindsay K. Caesar, Nadja B. Cech, Matthew E. Mead, Jacob L. Steenwyk, Lauren A. Ries, Gustavo H. Goldman, Antonis Rokas, Nicholas H. Oberlies
Frontiers in Microbiology
7) Mycopyranone: A 8,8'-binaphthopyranone with potent anti-MRSA activity from the fungus Phialemoniopsis sp.
Tetrahedron Letters 60(8): 594-597
2018
6) Phytochemical Analysis and Antimicrobial Efficacy of Macleaya cordata against Extensively Drug-Resistant Staphylococcus aureus
Manead Khin, Alan M. Jones, Nadja B. Cech, Lindsay K. Caesar
Natural Product Communications 13(11): 1479-1783
doi: 10.1177/1934578X1801301117
5) Analytical methods for the study of bioactive compounds from medicinally used Echinacea species
Renato Bruni, Virginia Brighenti, Lindsay K. Caesar, Davide Bertelli, Nadja B. Cech, Federica Pellati
Journal of Pharmaceutical and Biomedical Analysis 160: 443-477
doi: 10.1016/j/jpba.2018.07.044
4) Integration of Biochemometrics and Molecular Networking to Identify Antimicrobials in Angelica keiskei
Lindsay K. Caesar, Joshua J. Kellogg, Olav M. Kvalheim, Richard A. Cech, Nadja B. Cech
Planta medica, 84(9): 721-728
doi: 10.1055/a-590-5223
3) Hierarchical Cluster Analysis of Technical Replicates to Identify Interferents in Untargeted Mass Spectrometry Metabolomics
Lindsay K. Caesar, Olav M. Kvalheim, Nadja B. Cech
Analytica Chimica Acta, 1021: 69-77
2016
2) A Review of the Medicinal Uses and Pharmacology of Ashitaba
Lindsay K. Caesar, Nadja B. Cech
Planta Medica. 82(14): 1236-1245.
2015
1) Using a multifactor approach for improving stage II responses of Helleborus
hybrids in micropropagation
Lindsay K. Caesar, Jeffrey Adelberg
Propagation of Ornamental Plants. 15(4):125-135.
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